《血脈》是一部反映家庭倫理和社會(huì)倫理的都市情感劇。由江蘇文化產(chǎn)業(yè)集團(tuán)和南京傳奇影業(yè)有限公司聯(lián)手打造。該劇演職人員的陣容可圈可點(diǎn)：導(dǎo)演是來(lái)自馬來(lái)西亞的陳偉祥，曾成功執(zhí)導(dǎo)過(guò)多部在海內(nèi)外頗有影響力的影視劇，說(shuō)起他的弟弟、歌手阿牛可能知道的人更多。該劇的一號(hào)女演員苗乙乙曾經(jīng)出演過(guò)《牌坊下的女人》、《關(guān)東情事》、《笑傲江湖》等影視劇，其他主要演員朱永騰、劉思彤等人也都在演藝界頗有名氣。

　　摩特（杰弗里·塔伯 Jeffrey Tambor 飾）是一名德高望重的大學(xué)教授，雖然他和妻子雪梨（朱迪斯·賴(lài)特 Judith Light 飾）已經(jīng)離婚多年，但兩人之間還是維持著非常友好的來(lái)往。
　　摩特有三個(gè)孩子，大女兒沙拉（艾米·蘭德克 Amy Landecker 飾）家庭美滿(mǎn)婚姻幸福，但實(shí)際上，她一直都沒(méi)有忘記過(guò)自己在大學(xué)時(shí)代交往過(guò)的前女友。二兒子喬什（杰伊·杜普拉斯 Jay Duplass 飾）是樂(lè)隊(duì)經(jīng)紀(jì)人，感情生活一片混亂的他和自己樂(lè)隊(duì)的主唱有著不清不楚的曖昧關(guān)系。小女兒艾力（蓋比·霍夫曼 Gaby Hoffmann 飾）看似是三姐弟里最正常的一個(gè)人，但她也隱瞞著自己的秘密。一天，摩特告訴了自己的孩子們一個(gè)驚人的消息，他宣布自己一直以來(lái)都是一名跨性別者，自我認(rèn)知性別為女性。

　　Three years have passed since Patty and Ellen last worked together. Ellen reconnects with her high school friend, Chris Sanchez, who has recently returned from a stint at High Star, a private contractor in the Middle East. Unable to get assistance from the corporation or the government, Ellen decides to look into his case. Both her new boss and Patty warn Ellen about building a case against High Star Security Corp.

　　Almost a year has passed since Ellen Parsons left Hewes and Associates. She is now working in the District Attorney's office and is dealing with a fairly important drug case, trying to get a dealer to reveal the identity of his supplier. Patty Hewes is now acting on behalf of a group of investors trying to recover money they had entrusted to Louis Tobin and who, it turns out, was running a Ponzi scheme. With billions of dollars unaccounted for, Patty is trying to find any funds that may have been hidden by the Tobin family. Patty and Ellen have had no contact since her departure but Patty has been reluctant to re-assign her office, convinced that Ellen will return. She even sends her an expensive handbag. Ellen wants nothing to do with her however and when she thinks Patty may be interfering with her drug case, tells her she doesn't need any help. She also tells her that any secrets she may have are perfectly safe. In a flash-forward 6 months into the future, Patty Hewes is in a serious accident when another car broadsides her vehicle in an intersection. The occupant of the other vehicle has fled but it is registered to someone she knows.

　　Three months after the Frobisher settlement, Patty is concentrating on establishing a charitable foundation when an old boyfriend, named Daniel Purcell, contacts her and entangles her in a new case involving corporate fraud and greed. Meanwhile, Ellen continues working with the FBI to destroy Patty, but she becomes more rash and impatient as she continues to set up her appearances to hide her rage behind fabricated grief in the wake of David's murder. Elsewhere, Arthur Frobisher is revealed to have survived the assassination attempt and is recovering in seclusion as he plots his next move against all the people whom he felt wronged him.