該劇女主人公單玲玲是一個(gè)厭倦自己家庭和丈夫的下崗女工，為了改變現(xiàn)有的生活狀況，她不顧一切地想沖出婚姻枷鎖。在此同時(shí)，昔日的追求者，同樣經(jīng)歷過(guò)一次失敗婚姻，如今已是身價(jià)千萬(wàn)的大老板陸君的再次出現(xiàn)，更加堅(jiān)定了她離婚的信念。
　　而男主人公皮亞達(dá)卻是一個(gè)無(wú)所作為、不切實(shí)際，只能從和兒子吹牛中得到安慰的電影公司跑片員。他用美麗的謊言為兒子營(yíng)造了一個(gè)溫馨浪漫的童話世界。為了保護(hù)兒子，他不惜付出一切代價(jià)。但就是這樣一個(gè)不切實(shí)際的人，卻贏得了年輕貌美、特立獨(dú)行的編輯小彤的欣賞。
　　兒子皮特為了向同學(xué)證明自己不是單親家庭的孩子，在把長(zhǎng)相酷似單玲玲的袁老師幻想成自己母親的同時(shí)，通過(guò)各種方式去找尋自己棄家而走的母親。他調(diào)皮搗亂甚至不惜自殘生病來(lái)?yè)Q取母親的關(guān)注，希望因此能挽留住自己的母親重新回到這個(gè)家庭。但現(xiàn)實(shí)并未如他所愿，相反，父母為爭(zhēng)奪自己的扶養(yǎng)權(quán)卻鬧上了法庭……
　　該劇是以孩子與成人的雙重視角展示的家庭倫理劇。成人眼中許多司空見(jiàn)慣的事，在孩子眼中卻顯得那么觸目驚心、令人震撼，其視角獨(dú)特性為國(guó)內(nèi)電視劇市場(chǎng)所罕見(jiàn)。

　　尤佳期（陳喬恩 飾）和孟和平（馮紹峰 飾）是一對(duì)初戀情人，因?yàn)槊虾推侥赣H的阻撓而被迫分手，但雙方都不能忘卻昔日的感情。阮江西（路晨 飾）和阮正東（邱澤 飾）是一對(duì)兄妹，和孟和平是好朋友，家境富饒，過(guò)著名流貴族的生活。命運(yùn)一線牽將這四人緊緊聯(lián)系在了一起。阮江西一直愛(ài)戀著孟和平，孟和平雖對(duì)佳期舊情難忘，卻總是在一次又一次的誤會(huì)中與她錯(cuò)過(guò)，漸漸開(kāi)始正視西子的這份真情。阮正東熱烈的追求著尤佳期，在佳期過(guò)去的經(jīng)歷中感受到了佳期的善良，對(duì)她由游戲心態(tài)轉(zhuǎn)變?yōu)楫a(chǎn)生了真愛(ài)，然而命運(yùn)卻在他得知患了絕癥后發(fā)生了轉(zhuǎn)折。四人最終在這些感情的糾葛中，綻放出凄美的愛(ài)情之花…
　　根據(jù)匪我思存同名暢銷小說(shuō)《佳期如夢(mèng)》改編。

　　《血脈》是一部反映家庭倫理和社會(huì)倫理的都市情感劇。由江蘇文化產(chǎn)業(yè)集團(tuán)和南京傳奇影業(yè)有限公司聯(lián)手打造。該劇演職人員的陣容可圈可點(diǎn)：導(dǎo)演是來(lái)自馬來(lái)西亞的陳偉祥，曾成功執(zhí)導(dǎo)過(guò)多部在海內(nèi)外頗有影響力的影視劇，說(shuō)起他的弟弟、歌手阿?？赡苤赖娜烁?。該劇的一號(hào)女演員苗乙乙曾經(jīng)出演過(guò)《牌坊下的女人》、《關(guān)東情事》、《笑傲江湖》等影視劇，其他主要演員朱永騰、劉思彤等人也都在演藝界頗有名氣。

　　摩特（杰弗里·塔伯 Jeffrey Tambor 飾）是一名德高望重的大學(xué)教授，雖然他和妻子雪梨（朱迪斯·賴特 Judith Light 飾）已經(jīng)離婚多年，但兩人之間還是維持著非常友好的來(lái)往。
　　摩特有三個(gè)孩子，大女兒沙拉（艾米·蘭德克 Amy Landecker 飾）家庭美滿婚姻幸福，但實(shí)際上，她一直都沒(méi)有忘記過(guò)自己在大學(xué)時(shí)代交往過(guò)的前女友。二兒子喬什（杰伊·杜普拉斯 Jay Duplass 飾）是樂(lè)隊(duì)經(jīng)紀(jì)人，感情生活一片混亂的他和自己樂(lè)隊(duì)的主唱有著不清不楚的曖昧關(guān)系。小女兒艾力（蓋比·霍夫曼 Gaby Hoffmann 飾）看似是三姐弟里最正常的一個(gè)人，但她也隱瞞著自己的秘密。一天，摩特告訴了自己的孩子們一個(gè)驚人的消息，他宣布自己一直以來(lái)都是一名跨性別者，自我認(rèn)知性別為女性。

　　Three years have passed since Patty and Ellen last worked together. Ellen reconnects with her high school friend, Chris Sanchez, who has recently returned from a stint at High Star, a private contractor in the Middle East. Unable to get assistance from the corporation or the government, Ellen decides to look into his case. Both her new boss and Patty warn Ellen about building a case against High Star Security Corp.

　　Almost a year has passed since Ellen Parsons left Hewes and Associates. She is now working in the District Attorney's office and is dealing with a fairly important drug case, trying to get a dealer to reveal the identity of his supplier. Patty Hewes is now acting on behalf of a group of investors trying to recover money they had entrusted to Louis Tobin and who, it turns out, was running a Ponzi scheme. With billions of dollars unaccounted for, Patty is trying to find any funds that may have been hidden by the Tobin family. Patty and Ellen have had no contact since her departure but Patty has been reluctant to re-assign her office, convinced that Ellen will return. She even sends her an expensive handbag. Ellen wants nothing to do with her however and when she thinks Patty may be interfering with her drug case, tells her she doesn't need any help. She also tells her that any secrets she may have are perfectly safe. In a flash-forward 6 months into the future, Patty Hewes is in a serious accident when another car broadsides her vehicle in an intersection. The occupant of the other vehicle has fled but it is registered to someone she knows.

　　Three months after the Frobisher settlement, Patty is concentrating on establishing a charitable foundation when an old boyfriend, named Daniel Purcell, contacts her and entangles her in a new case involving corporate fraud and greed. Meanwhile, Ellen continues working with the FBI to destroy Patty, but she becomes more rash and impatient as she continues to set up her appearances to hide her rage behind fabricated grief in the wake of David's murder. Elsewhere, Arthur Frobisher is revealed to have survived the assassination attempt and is recovering in seclusion as he plots his next move against all the people whom he felt wronged him.